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MRCPUK SEND Exam Syllabus Topics:
| Section | Weight | Objectives |
|---|---|---|
| Topic 1: Adrenal and Parathyroid/Metabolic Bone Disorders | 15% | - Primary/secondary hyperaldosteronism - Cushing's syndrome, Addison's disease, phaeochromocytoma - Hyperparathyroidism, hypoparathyroidism - Osteoporosis, osteomalacia, Paget's disease |
| Topic 2: Reproductive and Other Endocrine Conditions | 15% | - Endocrine hypertension and rare syndromes - Polycystic ovary syndrome - Obesity and lipid disorders - Disorders of puberty and sex development |
| Topic 3: Pituitary and Hypothalamic Disorders | 15% | - Diabetes insipidus and SIADH - Hypopituitarism and hormone replacement - Hypothalamic dysfunction - Pituitary adenomas: prolactinoma, acromegaly, Cushing's disease |
| Topic 4: Diabetes Mellitus | 40% | - Type 2 Diabetes
|
| Topic 5: Thyroid Disorders | 15% | - Hypothyroidism and myxoedema coma - Thyroid nodules and cancer - Thyroiditis and subclinical dysfunction - Hyperthyroidism: Graves’ disease, toxic nodular disease |
MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
1. A 24-year-old man was referred for investigation of infertility. He had been having unprotected intercourse with his partner for 18 months, but the couple had failed to conceive. He had been treated for Hodgkin's lymphoma at the age of 17.
What is the most appropriate investigation?
A) serum testosterone
B) testicular biopsy
C) serum inhibin
D) serum follicle-stimulating hormone
E) semen analysis
2. A 34-year-old man was referred to the diabetes outpatient clinic with impaired glucose tolerance. He had a family history of diabetes mellitus and had a body mass index of 34.6 kg/m2 (18-25).
On examination, his blood pressure was 140/82 mmHg.
He wished to delay the onset of frank diabetes mellitus.
What is the most effective way of achieving this outcome?
A) orlistat
B) metformin
C) acarbose
D) ramipril
E) lifestyle changes aimed at weight loss
3. A 42-year-old woman, with type 1 diabetes mellitus of 22 years' duration, attended for annual review. She was using biphasic insulin twice daily and taking aspirin 75 mg, simvastatin 40 mg and ramipril 10 mg daily.
On examination, her blood pressure was 164/87 mmHg.
Investigations:
serum potassium5.9 mmol/L (3.5-4.9)
serum creatinine197 umol/L (60-110)
estimated glomerular filtration rate (MDRD)26 mL/min/1.73 m2 (>60)
haemoglobin A1c72 mmol/mol (20-42)
urinary albumin:creatinine ratio27.0 mg/mmol (<3.5)
urine culturenegative
What is the most important next step in management?
A) add furosemide
B) change to intensive insulin regimen
C) check bicarbonate
D) refer to a nephrologist
E) add aliskiren
4. A 26-year-old woman with previously well-controlled primary hypothyroidism had been an in patient for treatment of an eating disorder for the previous 6 weeks. She had a history of anaemia resulting from multiple vitamin deficiency and gastric erosions. She had been taking levothyroxine 125 micrograms daily for the previous 5 years; since admission her medication had also included ferrous sulfate, calcium and vitamin D, and sucralfate. Her daily medicines were taken under supervision at 09.00 h. Although she was eating better and had gained 4 kg in weight, she was now complaining of tiredness and feeling "worse than ever".
On examination, she was thin, slightly pale and had no palpable goitre. Recent blood tests had confirmed that her anaemia had resolved.
Investigations:
serum corrected calcium2.28 mmo/L (2.20-2.60)
serum thryoid-stimulating hormone12.0 mU/L (0.4-5.0)
serum free T48.0 pmol/L (10.0-22.0)
serum T30.90 nmol/L (1.07-3.18)
What is the most appropriate next step in management?
A) stop treatment with calcium and vitamin D
B) increase levothyroxine to 175 micrograms daily
C) administer levothyroxine alone at bedtime
D) add liothyronine 20 micrograms daily
E) no change in treatment
5. A 25-year-old woman presented with a solitary nodule in the right lobe of her thyroid gland.
Investigations:
serum thyroid-stimulating hormone0.45 mU/L (0.4-5.0)
serum free T420.7 pmol/L (10.0-22.0)
The presence of which feature would most increase the likelihood of malignancy?
A) elevated serum thyroglobulin concentration
B) microcalcification seen within the nodule on ultrasound scan
C) high titre of thyroid peroxidase antibodies
D) size of nodule >1.0 cm in maximum diameter
E) increased peripheral vascularity of nodule on Doppler ultrasound
Solutions:
| Question # 1 Answer: E | Question # 2 Answer: E | Question # 3 Answer: D | Question # 4 Answer: C | Question # 5 Answer: B |




