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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:
1. Many clinically important adverse drug reactions (ADRs) are detected after the marketing of a drug, rather than during premarketing clinical trials. Of the following, which is the primary reason for this phenomenon?
A) Pharmaceutical companies prefer to market agents with favorable side-effect profiles, so they focus premarketing studies on efficacy rather than on ADRs.
B) Too few patients are studied for too short a period of time during premarketing clinical trials.
C) Premarketing studies focus on efficacy rather than on safety; therefore, the study design accounts for the failure to detect ADRs.
D) Adverse reactions that are due to drug interactions or drug accumulation in renal insufficiency cannot be studied prospectively during the premarketing phase of clinical evaluation.
2. A study is conducted comparing two antibiotics for the treatment of UTIs. The results after 7 days of therapy demonstrated that Drug A was superior to Drug B in eradicating bacteria from the urine and eliminating signs and symptoms of infections. The investigators concluded that Drug A was significantly superior to Drug B (p<0.05). In subsequent studies, however, the two drugs were equivalent in efficacy.
Which one of the following types of error apparently occurred in the first study?
A) Type ||
B) Regression to the mean
C) Beta error
D) Type |
3. A physician suspects that a patient's symptoms are related to abrupt discontinuation of a certain drug and asks the pharmacotherapy specialist about common reactions in this type of situation.
A literature search produces one case report of a discontinuation syndrome involving the drug.
What is the most appropriate action to take with regard to the current suspected adverse event?
A) Complete a manufacturer's adverse event report.
B) Write and submit a case report detailing the event.
C) Report the event to the P & T Committee.
D) Report the event to the FDA MedWatch program.
4. A hospital requests a policy and procedure document for the monitoring and reporting of significant adverse drug reactions. Which agency requires a policy for the reporting of adverse drug reactions by hospitals?
A) National Committee for Quality Assurance
B) Institute for Safe medication Practices
C) Joint Commission
D) Food and Drug Administration
5. A 67-year-old patient is hospitalized for decompensated heart failure. The serum sodium concentration is 130 mEq/L on admission. Which of the following is the most appropriate approach to managing the patient's hyponatremia?
A) 3% NaCl 50 mL/h intravenously for 5 hours
B) Conivaptan 20 mg intravenously over 24 hours
C) 0.9% NaCl 200 mL/h intravenously for 5 hours
D) Restriction of both sodium and fluids
Solutions:
| Question # 1 Answer: B | Question # 2 Answer: D | Question # 3 Answer: B | Question # 4 Answer: D | Question # 5 Answer: D |




